Nicolas Nagot

Position in DATURA: Leader WP2, Clinical trial implementation, data management and analysis
Job title: Professor
Home Institutions: Montpellier University Hospital Centre (CHU) & University of Montpellier

First trained in France as a general practitioner with huge interest in tropical medicine, Dr. Nagot then specialised in clinical epidemiology in the UK. At the Montpellier University Hospital, he currently leads the Department of Clinical Research and serves as a methodologist for clinical trials. His two main research areas are to design and implement interventions, including large clinical trials. This research aims to control HIV and associated infections such as TB i) in vulnerable groups, and ii) in mother-to-child transmission through breastfeeding. His Montpellier group has implemented a large randomised controlled trial in 4 African countries which demonstrated that infant prophylaxis could greatly reduce postnatal HIV transmission.

In the field of TB, Nagot has set up a study in Zambia (UTH) to assess the potential diagnostic performance of innovative TB tests in children (publications under finalisation). These tests were designed in his research group. Nagot is currently the principal investigator of a NIH-funded quasi-experimental study evaluating the ability of a new intervention, based on a strong community involvement, to control HIV among people who inject drugs (PWID). In this population, they have recently documented that TB incidence and specific mortality were very high, and they are currently designing prevention and control measures to be evaluated in dedicated projects.