DATURA – Determination of Adequate TUberculosis Regimen in Adults and adolescents hospitalised with HIV-associated severe immune suppression

Newsletter for spring 2025

Posted on 22/07/2025 by rhe001

Please find the latest newsletter for 2025 here.

Finalization of Participant Enrollment

Posted on 25/02/2025 by rhe001

Participant enrollment in the DATURA study was completed in December 2024. However, participants will continue to be monitored until their final trial visit, which will occur 48 weeks after the initiation of anti-TB treatment. The last visit for the final Continue reading Finalization of Participant Enrollment→

First joint Project Steering Committee and Data and Safety Monitoring Board Meeting in 7-9 July 2024.

Posted on 12/08/2024 by rhe001

The first face-to-face DATURA joint Project Steering Committee (PSC) and Data and Safety Monitoring Board (DSMB) meeting took place on July 7-9, 2024 in Montpellier, France. Around 40 people, members of the 2 committees together with representatives of all participating Continue reading First joint Project Steering Committee and Data and Safety Monitoring Board Meeting in 7-9 July 2024.→

Newsletter for spring 2024

Posted on 08/07/2024 by rhe001

Please click on the post to find the latest newsletter of 2024.

All African trial sites have completed their first patient enrolment

Posted on 24/08/2022 by rhe001

It is with great pleasure to announce that all of the four trial sites in Africa have started to enroll patients in the DATURA program. The trial sites are located in Guinea, Cameroon, Zambia and Uganda. The latter received its Continue reading All African trial sites have completed their first patient enrolment→

First DATURA participant enrolled in Ignace Deen Hospital in Guinea

Posted on 13/05/2022 by rhe001

BREAKING NEWS: The first DATURA participant was enrolled in Ignace Deen Hospital, Conakry, Guinea on April 21st 2022. It is a 25-years old woman who just discovered her HIV status with CD4 count of 67 cells/µL. She has been enrolled Continue reading First DATURA participant enrolled in Ignace Deen Hospital in Guinea→

DATURA Mission to Guinea, Conakry – July 05-09th, 2021

Posted on 23/09/2021 by gmset

The visiting team was composed of Hicham ABOUINAN, international data manager, Jean-Pierre MOLES, laboratory coordinator, and Catherine QUILLET, international project manager, from the international coordinating trial unit. The Guinea team was led by Boubacar Djelo DIALLO, principal investigator, and Lansana Continue reading DATURA Mission to Guinea, Conakry – July 05-09th, 2021→

DATURA – a clinical trial

DATURA addresses people who are co-infected with TB and HIV. It is a research project that aims to assess whether an intensified initial TB treatment could increase survival in hospitalised, HIV-infected adults and adolescents compared to the standard TB treatment regime.

DATURA is registered in ClinicalTrials.gov : NCT04738812

Important DATURA dates:

Mozambique participated as a trial site by 2024, with first patient inclusion in February 15th, 2024
The European and Developing Countries Clinical Trials Partnership (EDCTP)signed the Grant 14 April 2020.
Official starting date of the project period is 1 May 2020. The project will last for 54 months from this date.
DATURA kick-off 14-15 Sept. 2020
First participant enrolled on April 21^st, 2022.
All African sites recruiting by August 2022.
EDCTP grant extended for an additional 14 months until December 2025.